Citations & Data


1.       MicroRNA-7 Specifically Marks the Gut Endocrine Lineage and Controls Progenitor Cell Proliferation Through Egfr. Singh AP, Hung Y, Bonfini A, Kanke M, Shanahan MT, Dame MK, Biraud M, Peck BC, Freund JM, Cubitt RL, Curry EG, Gonzalez LM, Dekaney CM,  Bewick GA, Kurpios NA, Ding S, Spence JR, Buchon N, Sethupathy P. Cell Press Sneak Preview (under review). Sept 2018.   

2.       Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroid-refractory GVHD. Golob, J. L., M. M. DeMeules, T. Loeffelholz, Z. Z. Quinn, M. K. Dame, S. S. Silvestri, M. C. Wu, T. M. Schmidt, T. L. Fiedler, M. J. Hoostal, M. Mielcarek, J. Spence, S. A. Pergam and D. N. Fredricks. Blood Advances. 2019;3(19):2866.

3.       Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity. Attili D, McClintock SD, Rizvi AH, Pandya S, Rehman H, Nadeem DM, Richter A, Thomas D, Dame MK, Turgeon DK, Varani J, Aslam MN. PLOS ONE, April 2019 DOI: 10.1371/journal.pone.0215122

4. Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation. Fan, S., Weight, C.M., Luissint, A.C., Hilgarth, R.S., Brazil, J.C., Ettel, M., Nusrat, A., and Parkos, C.A. Mol Biol Cell. 2019 Jan 9:mbcE18080531. doi: 10.1091/mbc.E18-08-0531. [Epub ahead of print]. PMID: 30625033

5. Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements. McClintock SD, Colacino JA, Attili D, Dame MK, Richter A, Reddy AR, Basrur V, Rizvi AH, Turgeon DK, Varani J, and Aslam MN.  Cancer Prev Res (Phila). 2018 Jul;11(7):413-428. doi: 10.1158/1940-6207.CAPR-17-0308. Epub 2018 Apr 10. PMCID: PMC6030430

6.       Lactobacillus rhamnosus GG prevents epithelial barrier dysfunction induced by interferon-gamma and fecal supernatants from irritable bowel syndrome patients in human intestinal enteroids and colonoids. Han X, Lee A, Huang S, Gao J, Spence JR, Owyang C. Gut Microbes. 2018 Jul 24:1-18. doi: 10.1080/19490976.2018.1479625. [Epub ahead of print]. PMID: 30040527

7.       A Method for Cryogenic Preservation of Human Biopsies and Subsequent Organoid Culture. Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, and Spence JR.  Cell Mol Gastroenterol Hepatol. 2018 May 30;6(2):218-222.e7. doi: 10.1016/j.jcmgh.2018.04.008. PMCID: PMC6085494

8.       Identification, isolation, and characterization of human LGR5-positive colon adenoma cells.  Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA. Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049. PMCID: PMC5897593

9.       Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids. Hill DR, Huang S, Tsai YH, Spence JR, Young VB. J Vis Exp. 2017 Dec 18;(130). doi: 10.3791/56960. PMCID: PMC5755602

10.       Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium. Hill DR, Huang S, Nagy MS, Yadagiri VK, Fields C, Mukherjee D, Bons B, Dedhia PH, Chin AM, Tsai YH, Thodla S, Schmidt TM, Walk S, Young VB, Spence JR. Elife. 2017 Nov 7;6. pii: e29132. doi: 10.7554/eLife.29132. PMCID: PMC5711377

11.       Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Xue X, Bredell BX, Anderson ER, Martin A, Mays C, Nagao-Kitamoto H, Huang S, Győrffy B, Greenson JK, Hardiman K, Spence JR, Kamada N, Shah YM. Proc Natl Acad Sci USA. 2017 Nov 7;114(45):E9608-E9617. doi: 10.1073/pnas.1712946114. Epub 2017 Oct 23. PMCID: PMC5692584

12.      BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER. Elife. 2017 Jan 10;6. pii: e20331. doi: 10.7554/eLife.20331. PMCID: PMC5268782